Publications highlights featuring BT scientists

BioTools Highlights New Research Advancing Chiral Drug Discovery

 

West Palm Beach, FL USA – {25 March 2025] – BioTools Inc. is pleased to spotlight a newly published peer-reviewed study titled “Biginelli dihydropyrimidines and their acetylated derivatives as L-/T-type calcium channel blockers: Synthesis, enantioseparation, and molecular modeling studies” by M. G. Gündüz & C. Dengiz, et al., appearing in Archiv der Pharmazie.

 

https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202400584

 

This research explores a class of Biginelli-derived dihydropyrimidines (DHPMs), structurally related to 1,4-dihydropyridines but with improved light stability and promising calcium-channel blocking activity. The work includes synthesis, acetylation, enantioseparation, and molecular modelling — all essential components in developing next-generation cardiovascular and neurological therapeutics.

 

BioTools’ Jordan Nafie participated in the research by determining absolute configuration using VCD.

 

We congratulate the research team on this important contribution to modern medicinal chemistry.

These remarkable molecules were recently named Molecule-of-the-Year 2024 by Chemical & Engineering News, and notably—their Absolute Configuration was determined using VCD.

🔗 C&EN Announcement: https://cen.acs.org/synthesis/Molecules-year-2024/102/i39
We’re proud to see VCD at the center of award-winning molecular research and are honored to contribute to scientific discoveries of this caliber. More innovations and collaborations are ahead—stay tuned!

New Scientific Highlight: VCD Helps Determine Absolute Configuration of C&EN’s Molecule-of-the-Year

As we enter 2025, we’re excited to showcase the latest publications featuring our signature technology: Vibrational Circular Dichroism (VCD). Each year, researchers around the world use VCD to unlock deeper structural insights—and we are proud to see this technique continuing to shape cutting-edge science.
Among this year’s exciting publications, one stands out prominently. A new paper from the group of Prof. Daniel Armstrong, completed in collaboration with the late Sir James Fraser Stoddart and our own Dr. Jordan Nafie, highlights groundbreaking work on mirror-image cyclodextrins:
🔗 Read the publication: https://pubs.acs.org/doi/10.1021/jacsau.4c00962

BioTools Inc. Celebrates Publication by Co-Founder Professor Laurence A. Nafie in Prestigious Journal

 

Jupiter, FL USA – {19 August 2023] – BioTools Inc. is delighted to highlight a groundbreaking publication, co-authored by our customers at Jagiellonian University and our co-founder, Prof.  Laurence A. Nafie, in Chemical Communications titled “Exceptionally enhanced Raman optical activity (ROA) of amyloid fibrils and their prefibrillar states”

(Vol. 59, 2023, 10793-10796, DOI: 10.1039/D3CC03216G). RSC Publishing

The study reveals that amyloid fibrils and their prefibrillar states exhibit an exceptionally large enhancement of ROA signals, indicating earlier detection of fibril formation compared to conventional methods such as circular dichroism (CD). This advancement holds significant promise for structural biology, neurodegenerative disease research, and the development of therapies targeting protein-misfolding conditions.

At BioTools Inc. — we are particularly excited by this work, as it underscores the importance of advanced chiroptical spectroscopic techniques in revealing subtle molecular and supramolecular structures. Prof. Nafie’s research aligns with our mission to provide high-resolution structural insight for drug discovery, protein therapeutics, and complex molecular systems.

We congratulate Prof. Nafie and his co-authors on this important contribution to the field. As the industry increasingly focuses on detailed molecular characterization, BioTools remains committed to advancing instrumentation and services — including ROA, VCD, and PROTA FT-IR— to support researchers in uncovering and validating molecular phenomena.

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