Absolute Configuration of Chiral Molecules by VCD

This week in the world of BioTools:

Recent Advances in the Application of Vibrational Circular Dichroism Spectroscopy for the Characterization of Asymmetric Catalysts

Prof. Dr. Christian Merten

Dedicated to Prof. Laurence A. Nafie, a pioneer of VCD spectroscopy, on the occasion of his 75th birthday.

Vibrational circular dichroism (VCD) spectroscopy, the chiroptical version of IR spectroscopy, is introduced as powerful a tool for the characterization of conformational preferences of asymmetric catalysts, catalyst‐reactant complexes, and activated species. Examples from ion‐pairing catalysis, hydrogen‐bonding organocatalysis, and enamine chemistry demonstrate that the computational analysis of VCD spectra can give deep insights into structural preferences of catalytically relevant species.

Dr. Yelena Pyatski will present a poster titled “The Sensitivity & Specificity of Raman and ROA Spectroscopy for Characterization of Carbohydrate Based Pharmaceuticals”.

3. What we are excited about:


Introducing ProtaCal™

ProtaCal™ offers, for the first time, a unified approach to structure characterization of proteins! This new software allows scientists to determine structure from several spectroscopic techniques: FT-IR, RAMAN / ROA, CD (Circular Dichroism).


Same databases. Same algorithm. By using the same algorithm and databases containing the same proteins, an error is eliminated. So, now you can TRUST the results when comparing different techniques.


Want to learn more? Want your spectrum analyzed? Visit the dedicated website where you can explore the different functions and submit your spectrum to our secure server.

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