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Absolute Configuration of Chiral Molecules by VCD

This week in the world of BioTools:

Recent Advances in the Application of Vibrational Circular Dichroism Spectroscopy for the Characterization of Asymmetric Catalysts

Prof. Dr. Christian Merten

Dedicated to Prof. Laurence A. Nafie, a pioneer of VCD spectroscopy, on the occasion of his 75th birthday.

Abstract
Vibrational circular dichroism (VCD) spectroscopy, the chiroptical version of IR spectroscopy, is introduced as powerful a tool for the characterization of conformational preferences of asymmetric catalysts, catalyst‐reactant complexes, and activated species. Examples from ion‐pairing catalysis, hydrogen‐bonding organocatalysis, and enamine chemistry demonstrate that the computational analysis of VCD spectra can give deep insights into structural preferences of catalytically relevant species.

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