ChiralIR-2X™
Vibrational Circular Dichroism (VCD) Spectrometer
BioTools was the first company to introduce a dedicated commercial instrument for the measurement of Vibrational Circular Dichroism (VCD). Since its introduction, the ChiralIR-2X™ has become the #1 selling VCD instrument, and the choice of pharmaceutical industry and regulatory agencies. In the second generation of this ‘product that took the field by storm’, we have introduced all digital processing, eliminated bulky electronics and made an upgrade to revolutionary DualPEM™ set-up a plug-and-play.
Instrument Features
- all digital processing
- Dual Source increases signal-to-noise ratio (S/N) of ~ 3.6 times over any single-source system
- simultaneous collection of IR and VCD spectra
- large detector dewar for 30-48-hour continuous measurements
- Optional DualPEM™ integration for improved stability and suppression of artifacts
Applications
- Characterization of fibrils
- Characterization of all types of chiral molecules
- Determination of absolute configuration without crystallization
- Direct measurement of enantiomeric excess without enantiomeric separation
Complete spectral range of measurements 4000-850 cm–1 (no change of filters required)
“
As a long-standing analytical chemist in pharmaceutical research with a focus on vibrational spectroscopy, I recognized the potential impact VCD could have on many aspects of big pharma. With the ChiralIR-2X™ I have successfully assigned the configurations of more than 600 exploratory drug molecules, providing an international service to research facilities in Europe and the United States. I consider this instrument to be world-class and a bargain for the price given its state-of-the art technology and incredible level of reliability.
-Mr. Douglas James Minick
Senior Research Investigator
GlaxoSmithKline
