Many small molecule bioactive and marketed drugs are chiral. They are often synthesised from commercially available chiral building blocks. However, chirality is sometimes incorrectly assigned by manufacturers with consequences for the end user ranging from: experimental irreproducibility, wasted time on synthesising the wrong product and reanalysis, to the added cost of purchasing the precursor and resynthesis of the correct stereoisomer.

Many small molecule bioactive and marketed drugs are chiral. They are often synthesised from commercially available chiral building blocks. However, chirality is sometimes incorrectly assigned by manufacturers with consequences for the end user ranging from: experimental irreproducibility, wasted time on synthesising the wrong product and reanalysis, to the added cost of purchasing the precursor and resynthesis of the correct stereoisomer.

We are excited to announce that BioTools has joined Rilas Innovation Center / RISE Lab in Woburn, MA! The facility will provide full lab services and will also include a demonstration lab. Starting with our award-winning VCD instrumentation for determination of absolute configuration of chiral molecules, we will soon add our cutting edge tools for […]

Probing the non-bonding interaction of small molecules with graphene oxide using DFT based vibrational circular dichroism By Omor Faruk Patwary, Muhammad; Mahbubur Rahman, M.; Khalid Bin Islam, Md; Ackas Ali, Md; Halim, Mohammad A.; Ahmed, Farid From Computational & Theoretical Chemistry (2022), 1207, 113503. Language: English, Database: CAPLUS DOI:10.1016/j.comptc.2021.113503 CLICK HERE Theoretical Prediction of Structures, […]

Dear customers, collaborators, partners & friends, All of you are at the top of our gratitude list this season! We are truly humbled and honored to be part of your research and product development and we continue to be inspired by you. Our team has worked hard to support the pharmaceutical industry and world class […]

New Partnerships; New Papers, Conferences and so much more…. End of Summer Newsletter

Prof Laurence Nafie will present a Lecture dedicated to Prof. Isao Noda on his receipt of the Pittsburgh Spectroscopy Award. We congratulate Prof. Noda, a long time friend and collaborator, on this Distinguished Award! Wed, March 10th | 9:15 – 9:50 AMOrigins and Information Content ofVibrational Optical Activity Spectraclick here for more info Virtual ConnectionsThat Matter!March […]

Congratulations to Med Chem Conference Award winners; new research and upcoming conferences

PROTEIN STRUCTURE: ONE SOFTWARE FOR ALL SPECTROSCOPIC TECHNIQUES Introducing ProtaCal™ ProtaCal™ offers, for the first time, a unified approach to structure characterization of proteins! This new software allows scientists to determine structure from several spectroscopic techniques: FT-IR, RAMAN / ROA, CD (Circular Dichroism). Same databases. Same algorithm. By using the same algorithm and databases containing […]

New Partnerships; New Papers, Conferences and so much more…. End of Summer Newsletter

In August, we held a giveaway in celebration of Professor Larry Nafie’s birthday. Congratulations to Dr. Darrell McCaslin of the University of Wisconsin, who won a signed copied of Larry’s book “Vibrational Optical Activity: Principles and Applications”

Featuring a review by Prof. Nafie based on his 2019 Chirality Medal Award address. ‌ Vibrational optical activity: From discovery and development to future challenges By Nafie Laurence A From Chirality (2020), 32(5), 667-692, Language: English, Database: MEDLINE CLICK HERE Up-to-date in 2020, there were over 50 papers published with VCD (Vibrational Circular Dichroism) and 16 papers […]

BioCell™ Short-pathlength cell for FT-IR and VCD/CD. Universally compatible with every FT-IR spectrometer. (available in July) BioJack-T™ w/ AccuTune™ BioCell holder jacket with flow adapters for temperature controlled studies. AccuTune provides precision tightening. (available now) TempCon-2X™ Pelltier based temperature controller Designed for use in FT-IR spec­trometers with large circular BioCell™ windows. The controller can be […]

Summer Update 2020

It is with great pleasure that we announce the upgrade of the ChiralIR software to Windows 10 that so many of you have been asking for. In addition to the upgrade in operating system, the new software also includes some other minor upgrades. To purchase an upgrade, please click here for the store. For academic institutions, please use coupon ACADEMIA15 […]

If you are part of the education community we encourage you to start teaching VCD to students. Help the next generation of scientists by giving the edge they need with new, innovative technology. Learn More About Teaching VCD

Join us in congratulating Professor Laurence Nafie, recipient of the Chirality Medal Winner 2019! On behalf of Vibrational Optical Activity users around the world, students, collaborators and employees of BioTools, we thank Professor Nafie for the pioneering and continued work on VCD & ROA. He is an inspiration for everything we do.Prof Nafie will accept this award at […]

The software tool automatically extracts energies from Guassian log files into an Excel spreadsheet.

Diastereomer Analysis: ID & Quant without separation Absolute Configuration without crystallization Enantiomeric Purity (%EE) without separation Conformer Analysis Continuous Chiral Process Monitoring Chiral and Achiral Impurities                                                         Stop by the […]

Papers on VCD & ROA published in 2017! Anal Sci. 2017;33(1):79-82. doi: 10.2116/analsci.33.79. Structural Discrimination between Aβ(1-40) and Aβ(1-42) Peptides in Films with Vibrational Circular Dichroism Spectroscopy. Morisaku T, Yui H. Phys Chem Chem Phys. 2017 Jan 18;19(3):2078-2086. doi: 10.1039/c6cp07828a. Raman optical activity of tetra-alanine in the poly(l-proline) II type peptide conformation. Furuta M, Fujisawa […]

The Florida Venture Forum is a statewide member based organization that helps entrepreneurs obtain funding through education, strategic partnering, and effective networking. The Forum hosts the annual Florida Venture Capital Conference™ that has been instrumental in helping Florida based entrepreneurs achieve almost $3 Billion in funding to date. Additionally, the Forum hosts the Florida Early […]

LOOK AT MOLECULES WITH A NEW TWIST OF LIGHT! Upgrade your existing FT-IR!Available for Thermo FT-IR model is50 and other models Download MANTIS flyer View  VCD video below: Read about VCD in USP: Vibrational circular dichroism (VCD), an important analytical method for determining the absolute configuration (AC) and purity of chiral molecules, has been published as a new […]

Join us as we congratulate BioTools customer, Professor Pedro Joseph-Nathan,  on receiving the 2016 Gerald Blunden Award, sponsored by the journal Natural Product Communications. Prof. Joseph-Nathan won the award with his review article “Vibrational Circular Dichrosim: Recent Advances for the Assignment of the Absolute Configuration of Natural Products” Natural Products Communications, 10 (10) 1785-1095 (2015), which is co-authored […]

Pittcon “The world’s leading annual conference andexposition on laboratory science” March 5 – 9, Chicago, IL BioTools Booth #1513 ACS National Meeting “Advanced Materials, Technologies, Systems and Processes” April 2 – 6, San Francisco, CA

BioTools is proud to congratulate Melody Sze on winning first place in the Palm Beach Regional Science and Engineering Fair for Excellence in Chemistry Research. Melody, a student at Suncoast High School, completed her summer internship at BioTools and continued her research with a project using the latest BioTools technology on the handheld Raman at […]

The RamTest, 532nm handheld Raman, was selected as a recipient of the distinguished The Analytical Scientist Innovation Award for 2016. The award highlights and celebrates the best analytical advances of the year and takes a look at how they will impact the scientific community. Read the article here RamTest White Papers RamTest White Papers Published […]

A collaboration with Dr. Igor Lednev, professor of chemistry and Director of the Lednev Research Laboratory on BioTools’ portable Raman.Contrary to TV shows like CSI, most crime scenes are not investigated by a well-trained team of professionals armed with the latest technology. In fact, the state of forensic science was so appalling in 2009 that […]

On June 1, 2016 USP released a second supplement to USP 39-NF 34 that became official on December 1, 2016. The supplement contains two chapters <782> and <1782> on Vibrational Circular Dichroism (VCD). The chapter <782> spells out in detail various aspects of VCD usage such as qualification of VCD spectrometers, sample measurements, validation and […]