On June 1, 2016 USP released a second supplement to USP 39-NF 34 that became official on December 1, 2016. The supplement contains two chapters <782> and <1782> on Vibrational Circular Dichroism (VCD). The chapter <782> spells out in detail various aspects of VCD usage such as qualification of VCD spectrometers, sample measurements, validation and verification of measured spectra. Chapter <1782> further explains with specific examples the instrumentation used, finer aspects on the qualitative and quantitative analysis, comparison between measured and calculated spectra, determination of enantiomeric excess, and concurrent use of VCD for absolute configuration and %EE
