BioTools Inc. is delighted to highlight a groundbreaking publication, co-authored by our customers at Jagiellonian University and our co-founder, Prof. Laurence A. Nafie, in Chemical Communications titled “Exceptionally enhanced Raman optical activity (ROA) of amyloid fibrils and their prefibrillar states”(Vol. 59, 2023, 10793-10796, DOI: 10.1039/D3CC03216G). RSC Publishing
The study reveals that amyloid fibrils and their prefibrillar states exhibit an exceptionally large enhancement of ROA signals, indicating earlier detection of fibril formation compared to conventional methods such as circular dichroism (CD). RSC Publishing This advancement holds significant promise for structural biology, neurodegenerative disease research, and the development of therapies targeting protein-misfolding conditions.
At BioTools Inc. — we are particularly excited by this work, as it underscores the importance of advanced chiroptical spectroscopic techniques in revealing subtle molecular and supramolecular structures. Prof. Nafie’s research aligns with our mission to provide high-resolution structural insight for drug discovery, protein therapeutics, and complex molecular systems. We congratulate Prof. Nafie and his co-authors on this important contribution to the field. As the industry increasingly focuses on detailed molecular characterization, BioTools remains committed to advancing instrumentation and services — including ROA, VCD, and PROTA FT-IR— to support researchers in uncovering and validating molecular phenomena.