BioTools Inc. is pleased to spotlight a newly published peer-reviewed study titled “Biginelli dihydropyrimidines and their acetylated derivatives as L-/T-type calcium channel blockers: Synthesis, enantioseparation, and molecular modeling studies” by M. G. Gündüz & C. Dengiz, et al., appearing in Archiv der Pharmazie.
https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202400584
This research explores a class of Biginelli-derived dihydropyrimidines (DHPMs), structurally related to 1,4-dihydropyridines but with improved light stability and promising calcium-channel blocking activity. The work includes synthesis, acetylation, enantioseparation, and molecular modelling — all essential components in developing next-generation cardiovascular and neurological therapeutics.
BioTools’ Jordan Nafie participated in the research by determining absolute configuration using VCD.
We congratulate the research team on this important contribution to modern medicinal chemistry.