Vibrational Circular Dichroism (VCD) spectrometer
BioTools was the first company to introduce a dedicated commercial instrument for the measurement of Vibrational Circular Dichroism (VCD). Since its introduction, the ChiralIR has become the #1 selling VCD instrument, and the choice of pharmaceutical industry and regulatory agencies. In the second generation of this ‘product that took the field by storm’, we have introduced all digital processing, eliminated bulky electronics and made an upgrade to revolutionary DualPEM set-up a plug-and-play. The result is a VCD instrument with:
- all digital processing and DualSource resulting in unparalleled signal to noise
- easy DualPEM integration for improved stability and suppression of artifacts
- simultaneous monitoring of IR and VCD signals
- large detector dewar for 36-48-hour continuous measurements
VCD in USP:
Vibrational circular dichroism (VCD), an important analytical method for determining the absolute configuration (AC) and purity of chiral molecules, has been published as a new “standard method” in the U. S. Pharmacopeia (USP 39-NF34, Chapters 782 and 1782). The chapters became official on December 1st, 2016.
The chapters were written by a consortium of scientists from key pharmaceutical companies and the two co-founders of BioTools, VCD experts Dr. Rina K. Dukor and Prof. Laurence A. Nafie. Chapter <782> details aspects of VCD usages including qualification of VCD spectrometers, sample measurements, validation, and verification of measured spectra. Chapter <1782> provides specific examples of instrumentation, finer points of qualitative and quantitative analysis, comparisons between measured and calculated spectra, determination of enantiomeric excess (%EE), and conconcurrent use of AC and %EE.