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Studies on a Type III Atropisomeric Colchicine Analog Enabled through an Intermolecular Oxidopyrylium (5 + 2) Cycloaddition/Reductive Ring-Opening Sequence

Many small molecule bioactive and marketed drugs are chiral. They are often synthesised from commercially available chiral building blocks. However, chirality is sometimes incorrectly assigned by manufacturers with consequences for the end user ranging from: experimental irreproducibility, wasted time on synthesising the wrong product and reanalysis, to the added cost of purchasing the precursor and resynthesis of the correct stereoisomer.

Studies on a Type III Atropisomeric Colchicine Analog Enabled through an Intermolecular Oxidopyrylium (5 + 2) Cycloaddition/Reductive Ring-Opening Sequence Read More »

Chirality: a key parameter in chemical probes

Many small molecule bioactive and marketed drugs are chiral. They are often synthesised from commercially available chiral building blocks. However, chirality is sometimes incorrectly assigned by manufacturers with consequences for the end user ranging from: experimental irreproducibility, wasted time on synthesising the wrong product and reanalysis, to the added cost of purchasing the precursor and resynthesis of the correct stereoisomer.

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BioTools is coming to Boston!

We are excited to announce that BioTools has joined Rilas Innovation Center / RISE Lab in Woburn, MA! The facility will provide full lab services and will also include a demonstration lab. Starting with our award-winning VCD instrumentation for determination of absolute configuration of chiral molecules, we will soon add our cutting edge tools for

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Hot papers in VCD & ROA Winter 2022

Probing the non-bonding interaction of small molecules with graphene oxide using DFT based vibrational circular dichroism By Omor Faruk Patwary, Muhammad; Mahbubur Rahman, M.; Khalid Bin Islam, Md; Ackas Ali, Md; Halim, Mohammad A.; Ahmed, Farid From Computational & Theoretical Chemistry (2022), 1207, 113503. Language: English, Database: CAPLUS DOI:10.1016/j.comptc.2021.113503 CLICK HERE Theoretical Prediction of Structures,

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Prof Laurence Nafie will present a Lecture dedicated to Prof. Isao Noda

Prof Laurence Nafie will present a Lecture dedicated to Prof. Isao Noda on his receipt of the Pittsburgh Spectroscopy Award. We congratulate Prof. Noda, a long time friend and collaborator, on this Distinguished Award! Wed, March 10th | 9:15 – 9:50 AMOrigins and Information Content ofVibrational Optical Activity Spectraclick here for more info Virtual ConnectionsThat Matter!March

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“Fall in love” with a brand new product!

PROTEIN STRUCTURE: ONE SOFTWARE FOR ALL SPECTROSCOPIC TECHNIQUES Introducing ProtaCal™ ProtaCal™ offers, for the first time, a unified approach to structure characterization of proteins! This new software allows scientists to determine structure from several spectroscopic techniques: FT-IR, RAMAN / ROA, CD (Circular Dichroism). Same databases. Same algorithm. By using the same algorithm and databases containing

“Fall in love” with a brand new product! Read More »

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